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EMD-18592
E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800
EMD-18592
Single-particle2.9 Å
Deposition: 04/10/2023Map released: 19/06/2024
Last modified: 02/07/2025
Sample Organism:
Escherichia coli,
Escherichia phage Mu
Sample: Ternary complex of E.coli DNA gyrase with 217 bp linear dsDNA fragment and LEI-800
Fitted models: 8qqi
Deposition Authors: Ghilarov D
,
Martin NI ,
van der Stelt M
Sample: Ternary complex of E.coli DNA gyrase with 217 bp linear dsDNA fragment and LEI-800
Fitted models: 8qqi
Deposition Authors: Ghilarov D
,
Martin NI ,
van der Stelt M
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.
Bakker AT,
Kotsogianni I ,
Avalos M ,
Punt JM ,
Liu B,
Piermarini D,
Gagestein B ,
Slingerland CJ ,
Zhang L,
Willemse JJ ,
Ghimire LB ,
van den Berg RJHBN,
Janssen APA ,
Ottenhoff THM ,
van Boeckel CAA,
van Wezel GP ,
Ghilarov D ,
Martin NI ,
van der Stelt M
(2024) Nat Chem , 16 , 1462 - 1472
,
Avalos M ,
Punt JM ,
Liu B,
Piermarini D,
Gagestein B ,
Slingerland CJ ,
Zhang L,
Willemse JJ ,
Ghimire LB ,
van den Berg RJHBN,
Janssen APA ,
Ottenhoff THM ,
van Boeckel CAA,
van Wezel GP ,
Ghilarov D ,
Martin NI ,
van der Stelt M
(2024) Nat Chem , 16 , 1462 - 1472
Grant Support:
- Wellcome Trust: 221868/Z/20/Z (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/P012523/1 (United Kingdom)
- European Research Council (ERC): 725523 (European Union)
- Netherlands Organisation for Scientific Research (NWO): 16444 (Netherlands)