Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-18230
Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide
EMD-18230
Single-particle3.71 Å
Deposition: 16/08/2023Map released: 21/02/2024
Last modified: 09/07/2025
Sample Organism:
Homo sapiens
Sample: Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide
Fitted models: 8q7r
Deposition Authors: Liwocha J
,
Prabu JR ,
Kleiger G,
Schulman BA
Sample: Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide
Fitted models: 8q7r
Deposition Authors: Liwocha J
,
Prabu JR ,
Kleiger G,
Schulman BA
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J ,
Purser N,
Liwocha J ,
Scott DC,
Byers HA,
Steigenberger B,
Hill S,
Tripathi-Giesgen I ,
Hinkle T,
Hansen FM,
Prabu JR ,
Radhakrishnan SK,
Kirkpatrick DS,
Reichermeier KM,
Schulman BA ,
Kleiger G
(2024) Mol Cell , 84 , 1304
,
Purser N,
Liwocha J ,
Scott DC,
Byers HA,
Steigenberger B,
Hill S,
Tripathi-Giesgen I ,
Hinkle T,
Hansen FM,
Prabu JR ,
Radhakrishnan SK,
Kirkpatrick DS,
Reichermeier KM,
Schulman BA ,
Kleiger G
(2024) Mol Cell , 84 , 1304
Grant Support:
- Max Planck Society: (Germany)