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EMD-17980
Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
EMD-17980
Single-particle3.02 Å
Deposition: 18/07/2023Map released: 12/02/2025
Last modified: 20/08/2025
Sample Organism:
Homo sapiens
Sample: BRISC dimer in complex with inhibitor FX-171-C
Fitted models: 8pvy
Deposition Authors: Chandler F
,
Zeqiraj E
Sample: BRISC dimer in complex with inhibitor FX-171-C
Fitted models: 8pvy
Deposition Authors: Chandler F
,
Zeqiraj E
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.
Chandler F ,
Reddy PAN,
Bhutda S,
Ross RL,
Datta A,
Walden M,
Walker K ,
Di Donato S,
Cassel JA,
Prakesch MA ,
Aman A ,
Datti A ,
Campbell LJ,
Foglizzo M ,
Bell L,
Stein DN,
Ault JR,
Al-Awar RS,
Calabrese AN ,
Sicheri F ,
Del Galdo F ,
Salvino JM ,
Greenberg RA ,
Zeqiraj E
(2025) Nat Struct Mol Biol
,
Reddy PAN,
Bhutda S,
Ross RL,
Datta A,
Walden M,
Walker K ,
Di Donato S,
Cassel JA,
Prakesch MA ,
Aman A ,
Datti A ,
Campbell LJ,
Foglizzo M ,
Bell L,
Stein DN,
Ault JR,
Al-Awar RS,
Calabrese AN ,
Sicheri F ,
Del Galdo F ,
Salvino JM ,
Greenberg RA ,
Zeqiraj E
(2025) Nat Struct Mol Biol
Grant Support:
- Wellcome Trust: 219997/Z/19/Z (United Kingdom)
- Wellcome Trust: (United Kingdom)