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EMD-17757
Cryo-EM structure of the Cas12m-crRNA-target DNA complex
EMD-17757
Single-particle2.93 Å
Deposition: 28/06/2023Map released: 07/02/2024
Last modified: 13/11/2024
Sample Organism:
Gordonia otitidis NBRC 100426,
synthetic construct
Sample: Cas12m protein in complex with crRNA and cognate DNA, Gordonia otitidis NBRC 100426 system
Fitted models: 8pm4
Deposition Authors: Sasnauskas G, Tamulaitiene G
,
Karvelis T ,
Bigelyte G,
Siksnys V
Sample: Cas12m protein in complex with crRNA and cognate DNA, Gordonia otitidis NBRC 100426 system
Fitted models: 8pm4
Deposition Authors: Sasnauskas G, Tamulaitiene G
,
Karvelis T ,
Bigelyte G,
Siksnys V
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.
Bigelyte G,
Duchovska B ,
Zedaveinyte R ,
Sasnauskas G,
Sinkunas T ,
Dalgediene I ,
Tamulaitiene G ,
Silanskas A ,
Kazlauskas D ,
Valancauskas L ,
Madariaga-Marcos J ,
Seidel R ,
Siksnys V ,
Karvelis T
(2024) Nucleic Acids Res , 52 , 3234 - 3248
,
Zedaveinyte R ,
Sasnauskas G,
Sinkunas T ,
Dalgediene I ,
Tamulaitiene G ,
Silanskas A ,
Kazlauskas D ,
Valancauskas L ,
Madariaga-Marcos J ,
Seidel R ,
Siksnys V ,
Karvelis T
(2024) Nucleic Acids Res , 52 , 3234 - 3248
Grant Support:
- Research Council of Lithuania: S-MIP-21-8 (Lithuania)