Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-17713
Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin
EMD-17713
Single-particle3.4 Å
Deposition: 23/06/2023Map released: 03/01/2024
Last modified: 09/07/2025
Sample Organism:
Homo sapiens
Sample: Complex of human CTLHSR4 E3 ligase bound to engineered ARMC8-specific VH and multiphosphorylated UBE2H~ubiquitin
Fitted models: 8pjn
Deposition Authors: Chrustowicz J, Sherpa D
,
Prabu RJ,
Schulman BA
Sample: Complex of human CTLHSR4 E3 ligase bound to engineered ARMC8-specific VH and multiphosphorylated UBE2H~ubiquitin
Fitted models: 8pjn
Deposition Authors: Chrustowicz J, Sherpa D
,
Prabu RJ,
Schulman BA
Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Chrustowicz J,
Sherpa D
,
Li J
,
Langlois CR,
Papadopoulou EC
,
Vu DT,
Hehl LA,
Karayel O,
Beier V,
von Gronau S,
Muller J,
Prabu JR,
Mann M,
Kleiger G,
Alpi AF
,
Schulman BA
(2024) Mol Cell , 84 , 293
,
Li J
,
Langlois CR,
Papadopoulou EC
,
Vu DT,
Hehl LA,
Karayel O,
Beier V,
von Gronau S,
Muller J,
Prabu JR,
Mann M,
Kleiger G,
Alpi AF
,
Schulman BA
(2024) Mol Cell , 84 , 293
Grant Support:
- Max Planck Society: (Germany)
- European Research Council (ERC): H2020 789016-NEDD8Activate (European Union)
- German Research Foundation (DFG): SCHU 3196/1-1 (Germany)
