Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-17580

Single-particle
3.5 Å
EMD-17580
3D View Gallery
Deposition: 08/06/2023
Map released: 07/02/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-17580
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8pb1 summary report (pdf.gz) Map and 8pb1 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.

EMD-17580

Single-particle
3.5 Å
EMD-17580
3D View Gallery
Deposition: 08/06/2023
Map released: 07/02/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Murine IL-12 in complex with mIL-12Rbeta1-DAPK1 and mIL-12Rbeta2-Calmodulin.
Fitted models: 8pb1

Deposition Authors: Felix J , Bloch Y , Savvides SN
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Bloch Y , Felix J , Merceron R, Provost M, Symakani RA , De Backer R , Lambert E, Mehdipour AR, Savvides SN
(2024) Nat Struct Mol Biol , 31 , 591 - 597
PUBMED: 38287195
DOI: doi:10.1038/s41594-023-01190-6
ISSN: 1545-9985