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EMD-17521
Cryo-EM structure of CAK in complex with inhibitor dinaciclib
EMD-17521
Single-particle1.9 Å
Deposition: 30/05/2023Map released: 20/03/2024
Last modified: 09/10/2024
Sample Organism:
Homo sapiens
Sample: CDK-activating kinase
Fitted models: 8p78
Deposition Authors: Cushing VI
,
Koh AF ,
Feng J,
Jurgaityte K ,
Bahl AK,
Ali S ,
Kotecha A ,
Greber BJ
Sample: CDK-activating kinase
Fitted models: 8p78
Deposition Authors: Cushing VI
,
Koh AF ,
Feng J,
Jurgaityte K ,
Bahl AK,
Ali S ,
Kotecha A ,
Greber BJ
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Cushing VI ,
Koh AF ,
Feng J,
Jurgaityte K ,
Bondke A,
Kroll SHB,
Barbazanges M ,
Scheiper B,
Bahl AK,
Barrett AGM ,
Ali S ,
Kotecha A ,
Greber BJ
(2024) Nat Commun , 15 , 2265 - 2265
,
Koh AF ,
Feng J,
Jurgaityte K ,
Bondke A,
Kroll SHB,
Barbazanges M ,
Scheiper B,
Bahl AK,
Barrett AGM ,
Ali S ,
Kotecha A ,
Greber BJ
(2024) Nat Commun , 15 , 2265 - 2265
Grant Support:
- Medical Research Council (MRC, United Kingdom): MR/V009354/1 (United Kingdom)