Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-17449
S. cerevisiae nexus-sCMGE after DNA replication initiation
EMD-17449
Single-particle3.9 Å
Deposition: 24/05/2023Map released: 29/05/2024
Last modified: 28/08/2024
Sample Organism:
Saccharomyces cerevisiae,
synthetic construct
Sample: Complex of Mcm2-7, Cdc45, GINS (Psf1-3, Sld5) DNA polymerase epsilon (subunit A and B), 19-mer DNA molecule with complementary 7-mer DNA molecule
Fitted models: 8p5e
Deposition Authors: Henrikus SS
,
Willhoft O
Sample: Complex of Mcm2-7, Cdc45, GINS (Psf1-3, Sld5) DNA polymerase epsilon (subunit A and B), 19-mer DNA molecule with complementary 7-mer DNA molecule
Fitted models: 8p5e
Deposition Authors: Henrikus SS
,
Willhoft O
Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Henrikus SS ,
Gross MH ,
Willhoft O,
Puhringer T,
Lewis JS ,
McClure AW ,
Greiwe JF ,
Palm G ,
Nans A ,
Diffley JFX ,
Costa A
(2024) Nat Struct Mol Biol , 31 , 1265 - 1276
,
Gross MH ,
Willhoft O,
Puhringer T,
Lewis JS ,
McClure AW ,
Greiwe JF ,
Palm G ,
Nans A ,
Diffley JFX ,
Costa A
(2024) Nat Struct Mol Biol , 31 , 1265 - 1276
Grant Support:
- The Francis Crick Institute: FC001065 and FC001066 (United Kingdom)
- European Research Council (ERC): grant agreement no. 820102 (European Union)
- Human Frontier Science Program (HFSP): LT000834/2020-L (France)
- European Molecular Biology Organization (EMBO): ALTF 962-2019 (European Union)