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EMD-17350

Single-particle
2.97 Å
EMD-17350
3D View Gallery
Deposition: 12/05/2023
Map released: 17/01/2024
Last modified: 31/01/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-17350
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8p1i summary report (pdf.gz) Map and 8p1i FULL report (pdf.gz)
EMICSS annotations (xml)

Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution

EMD-17350

Single-particle
2.97 Å
EMD-17350
3D View Gallery
Deposition: 12/05/2023
Map released: 17/01/2024
Last modified: 31/01/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940
Sample: Trimeric Klebsiella pneumoniae AcrB with BDM91288 efflux pump inhibitor
Fitted models: 8p1i

Deposition Authors: Boernsen C, Mueller RT, Pos KM , Frangakis AS
Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.
Vieira Da Cruz A, Jimenez-Castellanos JC, Bornsen C , Van Maele L , Compagne N, Pradel E , Muller RT, Meurillon V, Soulard D, Piveteau C, Biela A , Dumont J, Leroux F , Deprez B, Willand N, Pos KM , Frangakis AS , Hartkoorn RC , Flipo M
(2024) Embo Mol Med , 16 , 93 - 111
PUBMED: 38177534
DOI: doi:10.1038/s44321-023-00007-9
ISSN: 1757-4684