Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-17155
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)
EMD-17155
Single-particle6.2 Å
Deposition: 19/04/2023Map released: 24/05/2023
Last modified: 24/07/2024
Sample Organism:
Homo sapiens,
synthetic construct,
Mus musculus
Sample: CLOCK-BMAL1 bound to a nucleosome at SHL -6.2
Fitted models: 8osj
Deposition Authors: Michael AK
,
Stoos L,
Kempf G,
Cavadini S,
Thoma NH
Sample: CLOCK-BMAL1 bound to a nucleosome at SHL -6.2
Fitted models: 8osj
Deposition Authors: Michael AK
,
Stoos L,
Kempf G,
Cavadini S,
Thoma NH
Cooperation between bHLH transcription factors and histones for DNA access.
Michael AK ,
Stoos L,
Crosby P,
Eggers N ,
Nie XY ,
Makasheva K ,
Minnich M ,
Healy KL,
Weiss J ,
Kempf G,
Cavadini S,
Kater L,
Seebacher J,
Vecchia L,
Chakraborty D ,
Isbel L ,
Grand RS,
Andersch F ,
Fribourgh JL,
Schubeler D,
Zuber J ,
Liu AC ,
Becker PB ,
Fierz B ,
Partch CL ,
Menet JS ,
Thoma NH
(2023) Nature , 619 , 385 - 393
,
Stoos L,
Crosby P,
Eggers N ,
Nie XY ,
Makasheva K ,
Minnich M ,
Healy KL,
Weiss J ,
Kempf G,
Cavadini S,
Kater L,
Seebacher J,
Vecchia L,
Chakraborty D ,
Isbel L ,
Grand RS,
Andersch F ,
Fribourgh JL,
Schubeler D,
Zuber J ,
Liu AC ,
Becker PB ,
Fierz B ,
Partch CL ,
Menet JS ,
Thoma NH
(2023) Nature , 619 , 385 - 393
Grant Support:
- European Research Council (ERC): 884331 (European Union)
- Swiss National Science Foundation: CRSII5_186230 (Switzerland)
- Swiss National Science Foundation: 31003A_179541 (Switzerland)
- Swiss National Science Foundation: 310030_201206 (Switzerland)
- Human Frontier Science Program (HFSP): LT000646/2018-L5 (France)