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EMD-16383
Cryo-EM map of SARS-CoV-2 S-trimer (3 RBDs up) in complex with neutralizing sherpabody TriSb92
EMD-16383
Single-particle2.9 Å
Deposition: 21/12/2022Map released: 19/04/2023
Last modified: 20/11/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: SARS-CoV-2 Spike in open conformation with bound sherpabody
Fitted models: 8c1v
Deposition Authors: Huiskonen JT
,
Rissanen I ,
Hannula L
Sample: SARS-CoV-2 Spike in open conformation with bound sherpabody
Fitted models: 8c1v
Deposition Authors: Huiskonen JT
,
Rissanen I ,
Hannula L
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Makela AR,
Ugurlu H ,
Hannula L ,
Kant R ,
Salminen P ,
Fagerlund R,
Maki S ,
Haveri A ,
Strandin T ,
Kareinen L,
Hepojoki J ,
Kuivanen S,
Levanov L ,
Pasternack A ,
Naves RA,
Ritvos O ,
Osterlund P ,
Sironen T ,
Vapalahti O ,
Kipar A ,
Huiskonen JT ,
Rissanen I ,
Saksela K
(2023) Nat Commun , 14 , 1637 - 1637
,
Hannula L ,
Kant R ,
Salminen P ,
Fagerlund R,
Maki S ,
Haveri A ,
Strandin T ,
Kareinen L,
Hepojoki J ,
Kuivanen S,
Levanov L ,
Pasternack A ,
Naves RA,
Ritvos O ,
Osterlund P ,
Sironen T ,
Vapalahti O ,
Kipar A ,
Huiskonen JT ,
Rissanen I ,
Saksela K
(2023) Nat Commun , 14 , 1637 - 1637
Grant Support:
- Academy of Finland: 336492 (Finland)
- Academy of Finland: 342988 (Finland)