EMD-16104

Single-particle
3.3 Å
EMD-16104
3D View Gallery
Deposition: 09/11/2022
Map released: 15/05/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-16104

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8bla summary report (pdf.gz) Map-8bla FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human serotonin 5-HT3A receptor in complex with vortioxetine (detergent, ECD only, active/distorted conformation)

EMD-16104

Single-particle
3.3 Å
EMD-16104
3D View Gallery
Deposition: 09/11/2022
Map released: 15/05/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human serotonin 5-HT3A receptor
Fitted models: 8bla

Deposition Authors: Lopez-Sanchez U , Nury H
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.
Lopez-Sanchez U , Munro LJ, Ladefoged LK , Pedersen AJ, Brun CC, Lyngby SM, Baud D, Juillan-Binard C, Pedersen MG, Lummis SCR, Bang-Andersen B , Schiott B , Chipot C, Schoehn G , Neyton J, Dehez F , Nury H , Kristensen AS
(2024) Nat Struct Mol Biol , 31 , 1232 - 1242
PUBMED: 38698207
DOI: doi:10.1038/s41594-024-01282-x
ISSN: 1545-9985
Grant Support: