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EMD-16103
Human serotonin 5-HT3A receptor (apo, active/distorted conformation)
EMD-16103
Single-particle3.21 Å
Deposition: 09/11/2022Map released: 15/05/2024
Last modified: 02/07/2025
Sample Organism:
Homo sapiens
Sample: Human serotonin 5-HT3A receptor
Fitted models: 8bl8
Deposition Authors: Lopez-Sanchez U
,
Nury H
Sample: Human serotonin 5-HT3A receptor
Fitted models: 8bl8
Deposition Authors: Lopez-Sanchez U
,
Nury H
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.
Lopez-Sanchez U ,
Munro LJ,
Ladefoged LK ,
Pedersen AJ,
Brun CC,
Lyngby SM,
Baud D,
Juillan-Binard C,
Pedersen MG,
Lummis SCR,
Bang-Andersen B ,
Schiott B ,
Chipot C,
Schoehn G ,
Neyton J,
Dehez F ,
Nury H ,
Kristensen AS
(2024) Nat Struct Mol Biol , 31 , 1232 - 1242
,
Munro LJ,
Ladefoged LK ,
Pedersen AJ,
Brun CC,
Lyngby SM,
Baud D,
Juillan-Binard C,
Pedersen MG,
Lummis SCR,
Bang-Andersen B ,
Schiott B ,
Chipot C,
Schoehn G ,
Neyton J,
Dehez F ,
Nury H ,
Kristensen AS
(2024) Nat Struct Mol Biol , 31 , 1232 - 1242
Grant Support:
- European Research Council (ERC): 637733 (European Union)