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EMD-15899

Single-particle
4.02 Å
EMD-15899
3D View Gallery
Deposition: 30/09/2022
Map released: 05/04/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-15899
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8b7q summary report (pdf.gz) Map and 8b7q FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement

EMD-15899

Single-particle
4.02 Å
EMD-15899
3D View Gallery
Deposition: 30/09/2022
Map released: 05/04/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Mouse leptin in complex with a trimerized form of the mouse Lep-R extracellular region
Fitted models: 8b7q

Deposition Authors: Verstraete K , Savvides SN , Verschueren KG, Tsirigotaki A
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Tsirigotaki A, Dansercoer A, Verschueren KHG, Markovic I , Pollmann C , Hafer M, Felix J , Birck C , Van Putte W , Catteeuw D, Tavernier J , Fernando Bazan J, Piehler J , Savvides SN , Verstraete K
(2023) Nat Struct Mol Biol , 30 , 551 - 563
PUBMED: 36959263
DOI: doi:10.1038/s41594-023-00941-9
ISSN: 1545-9985