Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-15713
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
EMD-15713
Single-particle3.35 Å
Deposition: 02/09/2022Map released: 21/12/2022
Last modified: 09/10/2024
Sample Organism:
Homo sapiens,
Naja kaouthia
Sample: Complement C5-Inhibitor-CVF complex
Fitted models: 8ayh
Deposition Authors: Srinivas H
Sample: Complement C5-Inhibitor-CVF complex
Fitted models: 8ayh
Deposition Authors: Srinivas H
A small-molecule inhibitor of C5 complement protein.
Jendza K,
Kato M 
,
Salcius M ,
Srinivas H,
De Erkenez A,
Nguyen A,
McLaughlin D,
Be C,
Wiesmann C ,
Murphy J,
Bolduc P ,
Mogi M,
Duca J ,
Namil A,
Capparelli M,
Darsigny V,
Meredith E,
Tichkule R,
Ferrara L,
Heyder J,
Liu F,
Horton PA,
Romanowski MJ,
Schirle M,
Mainolfi N,
Anderson K,
Michaud GA
(2019) Nat Chem Biol , 15 , 666 - 668
,
Salcius M ,
Srinivas H,
De Erkenez A,
Nguyen A,
McLaughlin D,
Be C,
Wiesmann C ,
Murphy J,
Bolduc P ,
Mogi M,
Duca J ,
Namil A,
Capparelli M,
Darsigny V,
Meredith E,
Tichkule R,
Ferrara L,
Heyder J,
Liu F,
Horton PA,
Romanowski MJ,
Schirle M,
Mainolfi N,
Anderson K,
Michaud GA
(2019) Nat Chem Biol , 15 , 666 - 668
Grant Support:
- Other private: (Switzerland)