EMD-15713
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
EMD-15713
Single-particle3.35 Å
Deposition: 02/09/2022Map released: 21/12/2022
Last modified: 09/10/2024
Sample Organism:
Homo sapiens,
Naja kaouthia
Sample: Complement C5-Inhibitor-CVF complex
Fitted models: 8ayh
Deposition Authors: Srinivas H
Sample: Complement C5-Inhibitor-CVF complex
Fitted models: 8ayh
Deposition Authors: Srinivas H
A small-molecule inhibitor of C5 complement protein.
Jendza K,
Kato M 
,
Salcius M ,
Srinivas H,
De Erkenez A,
Nguyen A,
McLaughlin D,
Be C,
Wiesmann C ,
Murphy J,
Bolduc P ,
Mogi M,
Duca J ,
Namil A,
Capparelli M,
Darsigny V,
Meredith E,
Tichkule R,
Ferrara L,
Heyder J,
Liu F,
Horton PA,
Romanowski MJ,
Schirle M,
Mainolfi N,
Anderson K,
Michaud GA
(2019) Nat Chem Biol , 15 , 666 - 668
,
Salcius M ,
Srinivas H,
De Erkenez A,
Nguyen A,
McLaughlin D,
Be C,
Wiesmann C ,
Murphy J,
Bolduc P ,
Mogi M,
Duca J ,
Namil A,
Capparelli M,
Darsigny V,
Meredith E,
Tichkule R,
Ferrara L,
Heyder J,
Liu F,
Horton PA,
Romanowski MJ,
Schirle M,
Mainolfi N,
Anderson K,
Michaud GA
(2019) Nat Chem Biol , 15 , 666 - 668
Grant Support:
- Other private: (Switzerland)