Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-15677

Single-particle
4.43 Å
EMD-15677
3D View Gallery
Deposition: 26/08/2022
Map released: 05/04/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-15677
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8avb summary report (pdf.gz) Map and 8avb FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model)

EMD-15677

Single-particle
4.43 Å
EMD-15677
3D View Gallery
Deposition: 26/08/2022
Map released: 05/04/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Complex between mouse leptin and the mouse LEP-R ectodomain.
Fitted models: 8avb

Deposition Authors: Verstraete K , Savvides SN , Verschueren KG, Tsirigotaki A
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Tsirigotaki A, Dansercoer A, Verschueren KHG, Markovic I , Pollmann C , Hafer M, Felix J , Birck C , Van Putte W , Catteeuw D, Tavernier J , Fernando Bazan J, Piehler J , Savvides SN , Verstraete K
(2023) Nat Struct Mol Biol , 30 , 551 - 563
PUBMED: 36959263
DOI: doi:10.1038/s41594-023-00941-9
ISSN: 1545-9985