EMD-15588

Single-particle
2.92 Å
EMD-15588
3D View Gallery
Deposition: 13/08/2022
Map released: 01/03/2023
Last modified: 19/04/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-15588
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8aqs summary report (pdf.gz) Map and 8aqs FULL report (pdf.gz)
EMICSS annotations (xml)

BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)

EMD-15588

Single-particle
2.92 Å
EMD-15588
3D View Gallery
Deposition: 13/08/2022
Map released: 01/03/2023
Last modified: 19/04/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Severe acute respiratory syndrome coronavirus 2, Enterobacteria phage T4
Sample: BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)
Fitted models: 8aqs

Deposition Authors: Lau K , Ni D, Beckert B, Nazarov S, Myasnikov A, Pojer F, Stahlberg H, Uchikawa E
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E , Myasnikov A, Pojer F, Trono D, Stahlberg H, Lau K
(2023) PLoS Pathog , 19 , e1011206 - e1011206
PUBMED: 37018380
DOI: doi:10.1371/journal.ppat.1011206
ISSN: 1553-7374