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EMD-15417
human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
EMD-15417
Single-particle2.8 Å
Deposition: 19/07/2022Map released: 25/01/2023
Last modified: 24/07/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: MutSalpha on mismatched DNA
Fitted models: 8ag6
Deposition Authors: Bruekner SR, Sixma TK
Sample: MutSalpha on mismatched DNA
Fitted models: 8ag6
Deposition Authors: Bruekner SR, Sixma TK
Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Bruekner SR,
Pieters W ,
Fish A,
Liaci AM,
Scheffers S,
Rayner E ,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houlleberghs H,
Dubbink HJ ,
AlSaegh A,
de Wind N ,
Forster F ,
Te Riele H ,
Sixma TK
(2023) Nucleic Acids Res , 51 , 1173 - 1188
,
Fish A,
Liaci AM,
Scheffers S,
Rayner E ,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houlleberghs H,
Dubbink HJ ,
AlSaegh A,
de Wind N ,
Forster F ,
Te Riele H ,
Sixma TK
(2023) Nucleic Acids Res , 51 , 1173 - 1188
Grant Support:
- Netherlands Organisation for Scientific Research (NWO): NOW-TOP 714.016.002 (Netherlands)
- European Commission: H2020-MSCA-ITN-2016 722433 DNAREPAIRMAN (European Union)