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EMD-15243
Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic ecumicin (class 2)
EMD-15243
Single-particle8.59 Å
Deposition: 24/06/2022Map released: 31/05/2023
Last modified: 31/05/2023
Sample Organism:
Mycobacterium tuberculosis
Sample: Mycobacterium tuberculosis ClpC1 bound to the natural product antibiotic Ecumicin
Deposition Authors: Felix J
,
Fraga H ,
Gragera M,
Bueno T,
Weinhaeupl K
Sample: Mycobacterium tuberculosis ClpC1 bound to the natural product antibiotic Ecumicin
Deposition Authors: Felix J
,
Fraga H ,
Gragera M,
Bueno T,
Weinhaeupl K
Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
Weinhaupl K ,
Gragera M,
Bueno-Carrasco MT ,
Arranz R ,
Krandor O,
Akopian T,
Soares R,
Rubin E ,
Felix J ,
Fraga H
(2022) J Biol Chem , 298 , 102553 - 102553
,
Gragera M,
Bueno-Carrasco MT ,
Arranz R ,
Krandor O,
Akopian T,
Soares R,
Rubin E ,
Felix J ,
Fraga H
(2022) J Biol Chem , 298 , 102553 - 102553
Grant Support:
- Other government: iNEXT Discovery (871037) (European Union)
- Other government: CRIOMECORR project (ESFRI-2019-01-CSIC-16) (European Union)
- Other government: Instruct-ERIC (PID 15689) (European Union)