EMD-15242
Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin (class 1)
EMD-15242
Single-particle4.29 Å
Deposition: 24/06/2022Map released: 26/10/2022
Last modified: 24/07/2024
Sample Organism:
Mycobacterium tuberculosis
Sample: Mycobacterium tuberculosis ClpC1 bound to the natural product antibiotic Ecumicin
Fitted models: 8a8w
Deposition Authors: Felix J
,
Fraga H ,
Gragera M,
Bueno T,
Weinhaeupl K
Sample: Mycobacterium tuberculosis ClpC1 bound to the natural product antibiotic Ecumicin
Fitted models: 8a8w
Deposition Authors: Felix J
,
Fraga H ,
Gragera M,
Bueno T,
Weinhaeupl K
Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
Weinhaupl K ,
Gragera M,
Bueno-Carrasco MT ,
Arranz R ,
Krandor O,
Akopian T,
Soares R,
Rubin E ,
Felix J ,
Fraga H
(2022) J Biol Chem , 298 , 102553 - 102553
,
Gragera M,
Bueno-Carrasco MT ,
Arranz R ,
Krandor O,
Akopian T,
Soares R,
Rubin E ,
Felix J ,
Fraga H
(2022) J Biol Chem , 298 , 102553 - 102553
Grant Support:
- Other government: iNEXT Discovery (871037) (European Union)
- Other government: CRIOMECORR project (ESFRI-2019-01-CSIC-16) (European Union)
- Other government: Instruct-ERIC (PID 15689) (European Union)