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EMD-15022
CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
EMD-15022
Single-particle2.68 Å
Deposition: 24/05/2022Map released: 07/06/2023
Last modified: 24/07/2024
Sample Organism:
Homo sapiens
Sample: Ku70/80 hetero dimer bound to DNA, PAXX and XLF
Fitted models: 7zyg
Deposition Authors: Hardwick SW
,
Kefala-Stavridi A,
Chirgadze DY ,
Blundell TL ,
Chaplin AK
Sample: Ku70/80 hetero dimer bound to DNA, PAXX and XLF
Fitted models: 7zyg
Deposition Authors: Hardwick SW
,
Kefala-Stavridi A,
Chirgadze DY ,
Blundell TL ,
Chaplin AK
PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Seif-El-Dahan M,
Kefala-Stavridi A,
Frit P ,
Hardwick SW ,
Chirgadze DY ,
Maia De Oliviera T ,
Britton S ,
Barboule N,
Bossaert M ,
Pandurangan AP ,
Meek K ,
Blundell TL ,
Ropars V,
Calsou P ,
Charbonnier JB ,
Chaplin AK
(2023) Sci Adv , 9 , eadg2834 - eadg2834
,
Hardwick SW ,
Chirgadze DY ,
Maia De Oliviera T ,
Britton S ,
Barboule N,
Bossaert M ,
Pandurangan AP ,
Meek K ,
Blundell TL ,
Ropars V,
Calsou P ,
Charbonnier JB ,
Chaplin AK
(2023) Sci Adv , 9 , eadg2834 - eadg2834
Grant Support:
- Wellcome Trust: 200814/Z/16/Z; 2016 (United Kingdom)