Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-14776
Signal peptide mimicry primes Sec61 for client-selective inhibition
EMD-14776
Single-particle3.2 Å
Deposition: 13/04/2022Map released: 22/03/2023
Last modified: 15/11/2023
Sample Organism:
Ovis aries,
synthetic construct
Sample: Protein conducting Sec61 translocon complex
Fitted models: 7zl3
Deposition Authors: Rehan S
,
Paavilainen O V
Sample: Protein conducting Sec61 translocon complex
Fitted models: 7zl3
Deposition Authors: Rehan S
,
Paavilainen O V
Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S ,
Tranter D,
Sharp PP ,
Craven GB ,
Lowe E,
Anderl JL,
Muchamuel T,
Abrishami V ,
Kuivanen S,
Wenzell NA,
Jennings A,
Kalyanaraman C,
Strandin T ,
Javanainen M ,
Vapalahti O ,
Jacobson MP ,
McMinn D,
Kirk CJ,
Huiskonen JT ,
Taunton J ,
Paavilainen VO
(2023) Nat Chem Biol , 19 , 1054 - 1062
,
Tranter D,
Sharp PP ,
Craven GB ,
Lowe E,
Anderl JL,
Muchamuel T,
Abrishami V ,
Kuivanen S,
Wenzell NA,
Jennings A,
Kalyanaraman C,
Strandin T ,
Javanainen M ,
Vapalahti O ,
Jacobson MP ,
McMinn D,
Kirk CJ,
Huiskonen JT ,
Taunton J ,
Paavilainen VO
(2023) Nat Chem Biol , 19 , 1054 - 1062
Grant Support:
- Academy of Finland: 314672 (Finland)