EMD-14721

Single-particle
2.49 Å
EMD-14721
3D View Gallery
Deposition: 05/04/2022
Map released: 12/10/2022
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-14721

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7zh4 summary report (pdf.gz) Map-7zh4 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)

EMD-14721

Single-particle
2.49 Å
EMD-14721
3D View Gallery
Deposition: 05/04/2022
Map released: 12/10/2022
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: USP1 bound to ML323 and ubiquitin conjugated to FANCD2
Fitted models: 7zh4

Deposition Authors: Rennie ML , Walden H
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Rennie ML , Arkinson C, Chaugule VK, Walden H
(2022) Sci Adv , 8 , eabq6353 - eabq6353
PUBMED: 36170365
DOI: doi:10.1126/sciadv.abq6353
ISSN: 2375-2548