Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-14578
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Consensus Map)
EMD-14578
Single-particle3.12 Å
Deposition: 22/03/2022Map released: 30/03/2022
Last modified: 27/03/2024
Sample Organism:
Homo sapiens,
Escherichia coli K-12
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Deposition Authors: Coupland C, Carrique L
,
Siebold C
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Deposition Authors: Coupland C, Carrique L
,
Siebold C
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE ,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol Cell , 81 , 5025 - 5038.e10
,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol Cell , 81 , 5025 - 5038.e10
Grant Support:
- Cancer Research UK: C20724/A26752 (European Union)
- Cancer Research UK: C20724/A14414 (European Union)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/T01508X/1 (European Union)
- European Research Council (ERC): 647278 (European Union)