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EMD-14466

Single-particle
3.58 Å
EMD-14466
3D View Gallery
Deposition: 27/02/2022
Map released: 20/07/2022
Last modified: 17/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-14466
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7z2h summary report (pdf.gz) Map and 7z2h FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine

EMD-14466

Single-particle
3.58 Å
EMD-14466
3D View Gallery
Deposition: 27/02/2022
Map released: 20/07/2022
Last modified: 17/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human immunodeficiency virus type 1 BH10, synthetic construct
Sample: NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine
Fitted models: 7z2h

Deposition Authors: Singh AK , Das K
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Singh AK , De Wijngaert B , Bijnens M, Uyttersprot K, Nguyen H , Martinez SE, Schols D , Herdewijn P, Pannecouque C , Arnold E , Das K
(2022) PNAS , 119 , e2203660119 - e2203660119
PUBMED: 35858448
DOI: doi:10.1073/pnas.2203660119
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: