EMD-13984
Structure of Fibrillin Microfibrils from Cryo-Electron Microscopy reveals the site of latent TGFbeta binding and structural perturbations in disease-linked mutations
EMD-13984
Single-particle9.7 Å
Deposition: 14/12/2021Map released: 29/03/2023
Last modified: 13/12/2023
Sample Organism:
Bos taurus
Sample: Fibrillin-1 microfibril bead region
Deposition Authors: Godwin ARF
,
Thomson J,
Holmes DF,
Adamo CS
,
Sengle G,
Sherratt MJ,
Roseman AM
,
Baldock C
Sample: Fibrillin-1 microfibril bead region
Deposition Authors: Godwin ARF
,
Thomson J,
Holmes DF,
Adamo CS
,
Sengle G,
Sherratt MJ,
Roseman AM
,
Baldock C
Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGF beta-binding site.
Godwin ARF
,
Dajani R,
Zhang X,
Thomson J,
Holmes DF,
Adamo CS
,
Sengle G,
Sherratt MJ,
Roseman AM
,
Baldock C
(2023) Nat Struct Mol Biol , 30 , 608 - 618
,
Dajani R,
Zhang X,
Thomson J,
Holmes DF,
Adamo CS
,
Sengle G,
Sherratt MJ,
Roseman AM
,
Baldock C
(2023) Nat Struct Mol Biol , 30 , 608 - 618
Grant Support:
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/N015398/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/S015779/1 (United Kingdom)
