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EMD-13860
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
EMD-13860
Single-particle3.59 Å
Deposition: 09/11/2021Map released: 26/01/2022
Last modified: 20/11/2024
Sample Organism:
Homo sapiens,
Escherichia coli K-12
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Fitted models: 7q6z
Deposition Authors: Coupland C, Carrique L
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Fitted models: 7q6z
Deposition Authors: Coupland C, Carrique L
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE ,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol Cell , 81 , 5025 - 5038.e10
,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol Cell , 81 , 5025 - 5038.e10
Grant Support:
- Cancer Research UK: C20724/A26752 (European Union)
- Cancer Research UK: C20724/A14414 (European Union)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/T01508X/1 (European Union)
- European Research Council (ERC): 647278 (European Union)