EMD-13727

Helical reconstruction
3.6 Å
EMD-13727
3D View Gallery
Deposition: 12/10/2021
Map released: 20/04/2022
Last modified: 17/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-13727

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7pzd summary report (pdf.gz) Map-7pzd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the NLRP3 PYD filament

EMD-13727

Helical reconstruction
3.6 Å
EMD-13727
3D View Gallery
Deposition: 12/10/2021
Map released: 20/04/2022
Last modified: 17/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: filament formed by the human NLRP3 Pyrin domain
Fitted models: 7pzd

Deposition Authors: Hochheiser IV , Hagelueken G
Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.
Hochheiser IV , Behrmann H , Hagelueken G , Rodriguez-Alcazar JF , Kopp A , Latz E, Behrmann E , Geyer M
(2022) Sci Adv , 8 , eabn7583 - eabn7583
PUBMED: 35559676
DOI: doi:10.1126/sciadv.abn7583
ISSN: 2375-2548