EMD-13454

Single-particle
2.86 Å
EMD-13454
3D View Gallery
Deposition: 23/08/2021
Map released: 17/11/2021
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-13454

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7piv summary report (pdf.gz) Map-7piv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.

EMD-13454

Single-particle
2.86 Å
EMD-13454
3D View Gallery
Deposition: 23/08/2021
Map released: 17/11/2021
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct, Rattus norvegicus, Mus musculus, Lama glama
Sample: Ternary complex of the NDP-alpha-MSH activated melanocortin 4 receptor (MC4R) Gs protein complex stabilized by nanobody 35
Fitted models: 7piv

Deposition Authors: Heyder NA , Schmidt A , Kleinau G, Hilal T , Scheerer P
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Heyder NA , Kleinau G, Speck D , Schmidt A , Paisdzior S , Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D , Burger J , Mielke T , Beck-Sickinger AG , Hildebrand PW, Spahn CMT, Hilger D, Schacherl M , Biebermann H , Hilal T , Kuhnen P , Kobilka BK , Scheerer P
(2021) Cell Res , 31 , 1176 - 1189
PUBMED: 34561620
DOI: doi:10.1038/s41422-021-00569-8
ISSN: 1001-0602