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EMD-13453

Single-particle
2.58 Å
EMD-13453
3D View Gallery
Deposition: 23/08/2021
Map released: 17/11/2021
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-13453
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7piu summary report (pdf.gz) Map and 7piu FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the agonist setmelanotide bound to the activemelanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution

EMD-13453

Single-particle
2.58 Å
EMD-13453
3D View Gallery
Deposition: 23/08/2021
Map released: 17/11/2021
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct, Rattus norvegicus, Bos taurus, Lama glama
Sample: Ternary complex of setmelanotide-activated melanocortin 4 receptor with heterotrimeric Gs, further stabilized by addition of nanobody 35
Fitted models: 7piu

Deposition Authors: Heyder NA , Schmidt A , Kleinau G, Hilal T , Scheerer P
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Heyder NA , Kleinau G, Speck D , Schmidt A , Paisdzior S , Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D , Burger J , Mielke T , Beck-Sickinger AG , Hildebrand PW, Spahn CMT, Hilger D, Schacherl M , Biebermann H , Hilal T , Kuhnen P , Kobilka BK , Scheerer P
(2021) Cell Res , 31 , 1176 - 1189
PUBMED: 34561620
DOI: doi:10.1038/s41422-021-00569-8
ISSN: 1001-0602