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EMD-13378
Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
EMD-13378
Single-particle6.1 Å
Deposition: 11/08/2021Map released: 16/03/2022
Last modified: 16/10/2024
Sample Organism:
Homo sapiens
Sample: Uromodulin (UMOD)/Tamm-Horsfall protein (THP)
Fitted models: 7pfp
Deposition Authors: Jovine L
,
Xu C
Sample: Uromodulin (UMOD)/Tamm-Horsfall protein (THP)
Fitted models: 7pfp
Deposition Authors: Jovine L
,
Xu C
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Stsiapanava A,
Xu C,
Nishio S ,
Han L ,
Yamakawa N ,
Carroni M,
Tunyasuvunakool K,
Jumper J ,
de Sanctis D ,
Wu B ,
Jovine L
(2022) Nat Struct Mol Biol , 29 , 190 - 193
,
Han L ,
Yamakawa N ,
Carroni M,
Tunyasuvunakool K,
Jumper J ,
de Sanctis D ,
Wu B ,
Jovine L
(2022) Nat Struct Mol Biol , 29 , 190 - 193
Secondary citations:
- Jovine L, Qi H, Williams Z, Litscher E & Wassarman PM. (2002) The ZP domain is a conserved module for polymerization of extracellular proteins. 4, 457 - 461
- Serafini-Cessi F, Malagolini N & Cavallone D. (2003) Tamm-Horsfall glycoprotein: biology and clinical relevance. 42, 658 - 676
- Jovine L, Qi H, Williams Z, Litscher ES & Wassarman PM. (2004) A duplicated motif controls assembly of zona pellucida domain proteins. PNAS, 101, 5922 - 5927
- Yang H, Wu C, Zhao S & Guo J. (2004) Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. FEBS Lett, 578, 236 - 238
- Schaeffer C, Santambrogio S, Perucca S, Casari G & Rampoldi L. (2009) Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly. Mol Biol Cell, 20, 589 - 599
- Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, Schaeffer C, Olinger E, Peng J, Santambrogio S, Perrier R, Li S, Bokhove M, Bachi A, Hummler E, Devuyst O, Wu Q, Jovine L & Rampoldi L. (2015) The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. eLife, 4, e08887
- Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L & Jovine L. (2016) A structured interdomain linker directs self-polymerization of human uromodulin. PNAS, 113, 1552 - 1557
- Bokhove M & Jovine L. (2018) Structure of Zona Pellucida Module Proteins. 130, 413 - 442
- Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B & Jovine L. (2020) Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. EMBO J, 39, e106807
- Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Zidek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, Senior AW, Kavukcuoglu K, Kohli P & Hassabis D. (2021) Highly accurate protein structure prediction with AlphaFold. Nature,
Grant Support:
- Swedish Research Council: 2016-03999 (Sweden)
- Swedish Research Council: 2020-04936 (Sweden)
- Knut and Alice Wallenberg Foundation: 2018.0042 (Sweden)
- Ministry of Education (MoE, Singapore): MOH-000382-00 (Sweden)