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EMD-13140

Single-particle
2.71 Å
EMD-13140
3D View Gallery
Deposition: 29/06/2021
Map released: 15/12/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-13140
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7p00 summary report (pdf.gz) Map and 7p00 FULL report (pdf.gz)
EMICSS annotations (xml)

Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex

EMD-13140

Single-particle
2.71 Å
EMD-13140
3D View Gallery
Deposition: 29/06/2021
Map released: 15/12/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: NK1R in complex with Substance P, heterotrimeric mini-Gq chimera (Gsqi) and scFv16
Fitted models: 7p00

Deposition Authors: Thom C , Ehrenmann J
Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Thom C , Ehrenmann J , Vacca S , Waltenspuhl Y , Schoppe J , Medalia O , Pluckthun A
(2021) Sci Adv , 7 , eabk2872 - eabk2872
PUBMED: 34878828
DOI: doi:10.1126/sciadv.abk2872
ISSN: 2375-2548