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EMD-13077
Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir
EMD-13077
Single-particle3.5 Å
Deposition: 11/06/2021Map released: 18/08/2021
Last modified: 17/07/2024
Sample Organism:
Simian T-lymphotropic virus 1,
Homo sapiens
Sample: Complex of STLV-1 MarB43 integrase with nascent viral DNA, the human PP2A B56 subunit and the drug inhibitor bictegravir
Fitted models: 7ouh
Deposition Authors: Barski MS
,
Ballandras-Colas A
Sample: Complex of STLV-1 MarB43 integrase with nascent viral DNA, the human PP2A B56 subunit and the drug inhibitor bictegravir
Fitted models: 7ouh
Deposition Authors: Barski MS
,
Ballandras-Colas A
Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
Barski MS ,
Vanzo T ,
Zhao XZ ,
Smith SJ ,
Ballandras-Colas A ,
Cronin NB ,
Pye VE ,
Hughes SH ,
Burke Jr TR ,
Cherepanov P ,
Maertens GN
(2021) Nat Commun , 12 , 4996 - 4996
,
Vanzo T ,
Zhao XZ ,
Smith SJ ,
Ballandras-Colas A ,
Cronin NB ,
Pye VE ,
Hughes SH ,
Burke Jr TR ,
Cherepanov P ,
Maertens GN
(2021) Nat Commun , 12 , 4996 - 4996
Grant Support:
- Wellcome Trust: 107005/Z/15Z (United Kingdom)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): GM082251 (United States)
- The Francis Crick Institute: FC001061 (United Kingdom)
- Wellcome Trust: 206175/Z/17/Z (United Kingdom)