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EMD-12777
Nanobody C5 bound to Spike
EMD-12777
Single-particle3.0 Å
Deposition: 19/04/2021Map released: 11/08/2021
Last modified: 23/10/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Vicugna pacos
Sample: nanobody complex
Fitted models: 7oan
Deposition Authors: Naismith JH, Weckener M
Sample: nanobody complex
Fitted models: 7oan
Deposition Authors: Naismith JH, Weckener M
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Huo J 
,
Mikolajek H,
Le Bas A ,
Clark JJ ,
Sharma P,
Kipar A,
Dormon J,
Norman C ,
Weckener M,
Clare DK ,
Harrison PJ,
Tree JA ,
Buttigieg KR,
Salguero FJ,
Watson R ,
Knott D,
Carnell O ,
Ngabo D ,
Elmore MJ ,
Fotheringham S,
Harding A,
Moynie L ,
Ward PN ,
Dumoux M ,
Prince T ,
Hall Y,
Hiscox JA,
Owen A ,
James W ,
Carroll MW,
Stewart JP ,
Naismith JH,
Owens RJ
(2021) Nat Commun , 12 , 5469 - 5469
,
Mikolajek H,
Le Bas A ,
Clark JJ ,
Sharma P,
Kipar A,
Dormon J,
Norman C ,
Weckener M,
Clare DK ,
Harrison PJ,
Tree JA ,
Buttigieg KR,
Salguero FJ,
Watson R ,
Knott D,
Carnell O ,
Ngabo D ,
Elmore MJ ,
Fotheringham S,
Harding A,
Moynie L ,
Ward PN ,
Dumoux M ,
Prince T ,
Hall Y,
Hiscox JA,
Owen A ,
James W ,
Carroll MW,
Stewart JP ,
Naismith JH,
Owens RJ
(2021) Nat Commun , 12 , 5469 - 5469
Grant Support:
- Wellcome Trust: 100209/Z/12/Z) (United Kingdom)
- Engineering and Physical Sciences Research Council: EP/S025243/1 (United Kingdom)