EMD-12765

Single-particle
3.5 Å
EMD-12765
3D View Gallery
Deposition: 17/04/2021
Map released: 12/01/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-12765

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7o9w summary report (pdf.gz) Map-7o9w FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Encequidar-bound human P-glycoprotein in complex with UIC2-Fab

EMD-12765

Single-particle
3.5 Å
EMD-12765
3D View Gallery
Deposition: 17/04/2021
Map released: 12/01/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Nanodisc reconstituted human P-glycoprotein in complex with UIC2-Fab and encequidar
Fitted models: 7o9w

Deposition Authors: Nosol K , Locher KP
Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
Urgaonkar S , Nosol K , Said AM, Nasief NN, Bu Y, Locher KP , Lau JYN, Smolinski MP
(2022) J Med Chem , 65 , 191 - 216
PUBMED: 34928144
DOI: doi:10.1021/acs.jmedchem.1c01272
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: