EMD-12593
Amyloid-beta fibril of the Uppsala variant (polymorph 2)
EMD-12593
Helical reconstruction5.1 Å
Deposition: 11/03/2021Map released: 06/07/2022
Last modified: 06/07/2022
Sample Organism:
Homo sapiens
Sample: amyloid fibril of Abeta36
Deposition Authors: Zielinski M
,
Willbold D ,
Schroder GF
Sample: amyloid fibril of Abeta36
Deposition Authors: Zielinski M
,
Willbold D ,
Schroder GF
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation.
Pagnon de la Vega M ,
Giedraitis V ,
Michno W ,
Kilander L,
Guner G ,
Zielinski M ,
Lowenmark M,
Brundin R,
Danfors T ,
Soderberg L,
Alafuzoff I,
Nilsson LNG,
Erlandsson A ,
Willbold D ,
Muller SA ,
Schroder GF ,
Hanrieder J ,
Lichtenthaler SF ,
Lannfelt L,
Sehlin D ,
Ingelsson M
(2021) Sci Transl Med , 13
,
Giedraitis V ,
Michno W ,
Kilander L,
Guner G ,
Zielinski M ,
Lowenmark M,
Brundin R,
Danfors T ,
Soderberg L,
Alafuzoff I,
Nilsson LNG,
Erlandsson A ,
Willbold D ,
Muller SA ,
Schroder GF ,
Hanrieder J ,
Lichtenthaler SF ,
Lannfelt L,
Sehlin D ,
Ingelsson M
(2021) Sci Transl Med , 13