EMD-12295

Single-particle
3.39 Å
EMD-12295
3D View Gallery
Deposition: 05/02/2021
Map released: 21/04/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-12295

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7nez summary report (pdf.gz) Map-7nez FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Structure of topotecan-bound ABCG2

EMD-12295

Single-particle
3.39 Å
EMD-12295
3D View Gallery
Deposition: 05/02/2021
Map released: 21/04/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Multidrug transporter ABCG2 with bound substrate topotecan and 5D3-Fab variable domain
Fitted models: 7nez

Deposition Authors: Kowal J , Locher K
Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
Kowal J , Ni D, Jackson SM, Manolaridis I, Stahlberg H , Locher KP
(2021) J Mol Biol , 433 , 166980 - 166980
PUBMED: 33838147
DOI: doi:10.1016/j.jmb.2021.166980
ISSN: 1089-8638
ASTM: JMOBAK
Grant Support: