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EMD-12294

Helical reconstruction
4.3 Å
EMD-12294
3D View Gallery
Deposition: 04/02/2021
Map released: 01/12/2021
Last modified: 01/12/2021
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-12294
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class)

EMD-12294

Helical reconstruction
4.3 Å
EMD-12294
3D View Gallery
Deposition: 04/02/2021
Map released: 01/12/2021
Last modified: 01/12/2021
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Pseudomonas virus phi6
Sample: M854K MDA5-dsRNA filament in complex with ADP-AlF4(major class)

Deposition Authors: Yu Q , Modis Y
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Yu Q , Herrero Del Valle A , Singh R , Modis Y
(2021) Nat Commun , 12 , 6668 - 6668
PUBMED: 34795277
DOI: doi:10.1038/s41467-021-27062-5
ISSN: 2041-1723
Grant Support: