EMD-12214
human complex II-BATS bound to membrane-attached Rab5a-GTP
EMD-12214
Subtomogram averaging9.8 Å
Deposition: 17/01/2021Map released: 03/03/2021
Last modified: 01/05/2024
Sample Organism:
Homo sapiens
Sample: human VPS34 complex II (VPS34-VPS15-Beclin1-UVRAG) bound to human Rab5a
Fitted models: 7bl1
Deposition Authors: Tremel S
,
Morado DR
Sample: human VPS34 complex II (VPS34-VPS15-Beclin1-UVRAG) bound to human Rab5a
Fitted models: 7bl1
Deposition Authors: Tremel S
,
Morado DR
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Tremel S ,
Ohashi Y ,
Morado DR,
Bertram J,
Perisic O ,
Brandt LTL ,
von Wrisberg MK ,
Chen ZA ,
Maslen SL ,
Kovtun O ,
Skehel M ,
Rappsilber J,
Lang K ,
Munro S ,
Briggs JAG,
Williams RL
(2021) Nat Commun , 12 , 1564 - 1564
,
Ohashi Y ,
Morado DR,
Bertram J,
Perisic O ,
Brandt LTL ,
von Wrisberg MK ,
Chen ZA ,
Maslen SL ,
Kovtun O ,
Skehel M ,
Rappsilber J,
Lang K ,
Munro S ,
Briggs JAG,
Williams RL
(2021) Nat Commun , 12 , 1564 - 1564
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_U105184308 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_U10517878 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/16 (United Kingdom)
- Cancer Research UK: C14801/A21211
- European Research Council (ERC): ERC-CoG-648432 MEMBRANEFUSION (United Kingdom)
- Wellcome Trust: No. 103139 (United Kingdom)
- Wellcome Trust: No. 203149 (United Kingdom)