EMD-12213

Helical reconstruction
2.8 Å
EMD-12213
3D View Gallery
Deposition: 16/01/2021
Map released: 17/11/2021
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-12213

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7bkp summary report (pdf.gz) Map-7bkp FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP

EMD-12213

Helical reconstruction
2.8 Å
EMD-12213
3D View Gallery
Deposition: 16/01/2021
Map released: 17/11/2021
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Pseudomonas virus phi6, Mus musculus
Sample: M854K MDA5-dsRNA filament in complex with ATP
Fitted models: 7bkp

Deposition Authors: Singh R , Herrero del Valle A
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Yu Q , Herrero Del Valle A , Singh R , Modis Y
(2021) Nat Commun , 12 , 6668 - 6668
PUBMED: 34795277
DOI: doi:10.1038/s41467-021-27062-5
ISSN: 2041-1723
Grant Support: