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EMD-12142
ASCT2 in the presence of the inhibitor Lc-BPE in the outward-open conformation.
EMD-12142
Single-particle3.43 Å
Deposition: 21/12/2020Map released: 22/09/2021
Last modified: 10/07/2024
Sample Organism:
Homo sapiens
Sample: ASCT2 in the presence of the inhibitor Lc-BPE in the outward-open conformation.
Fitted models: 7bcq
Deposition Authors: Garibsingh RA
,
Ndaru E
Sample: ASCT2 in the presence of the inhibitor Lc-BPE in the outward-open conformation.
Fitted models: 7bcq
Deposition Authors: Garibsingh RA
,
Ndaru E
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Garibsingh RA ,
Ndaru E ,
Garaeva AA ,
Shi Y,
Zielewicz L,
Zakrepine P,
Bonomi M ,
Slotboom DJ ,
Paulino C ,
Grewer C ,
Schlessinger A
(2021) PNAS , 118
,
Ndaru E ,
Garaeva AA ,
Shi Y,
Zielewicz L,
Zakrepine P,
Bonomi M ,
Slotboom DJ ,
Paulino C ,
Grewer C ,
Schlessinger A
(2021) PNAS , 118
Grant Support:
- Netherlands Organisation for Scientific Research (NWO): 722.017.001 (Netherlands)
- Netherlands Organisation for Scientific Research (NWO): 740.018.016 (Netherlands)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01 GM108911 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): T32 CA078207 (United States)
- National Science Foundation (NSF, United States): 1515028 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R15 GM135843-01 (United States)
- Netherlands Organisation for Scientific Research (NWO): 714.018.003 (Netherlands)