EMD-11927

Single-particle
2.97 Å
EMD-11927
3D View Gallery
Deposition: 02/11/2020
Map released: 28/04/2021
Last modified: 15/03/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-11927

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7aue summary report (pdf.gz) Map-7aue FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Melanocortin receptor 4 (MC4R) Gs protein complex

EMD-11927

Single-particle
2.97 Å
EMD-11927
3D View Gallery
Deposition: 02/11/2020
Map released: 28/04/2021
Last modified: 15/03/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus, synthetic construct
Sample: Melanocortine 4 (MC4R) - GalphaS protein comlex
Fitted models: 7aue

Deposition Authors: Degtjarik O , Israeli H , Prabahar V , Shalev-Benami M
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Israeli H , Degtjarik O , Fierro F , Chunilal V , Gill AK , Roth NJ, Botta J , Prabahar V , Peleg Y , Chan LF , Ben-Zvi D , McCormick PJ , Niv MY , Shalev-Benami M
(2021) Science , 372 , 808 - 814
PUBMED: 33858992
DOI: doi:10.1126/science.abf7958
ISSN: 1095-9203
ASTM: SCIEAS