EMD-11679
Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
EMD-11679
Single-particle3.5 Å
Deposition: 30/08/2020Map released: 30/12/2020
Last modified: 01/05/2024
Sample Organism:
Homo sapiens
Sample: Human POLRMT (lacking residues 1-104) in complex with IMT inhibitor.
Fitted models: 7a8p
Deposition Authors: Hillen HS
,
Bonekamp N
Sample: Human POLRMT (lacking residues 1-104) in complex with IMT inhibitor.
Fitted models: 7a8p
Deposition Authors: Hillen HS
,
Bonekamp N
Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA ,
Peter B ,
Hillen HS ,
Felser A ,
Bergbrede T ,
Choidas A ,
Horn M ,
Unger A ,
Di Lucrezia R ,
Atanassov I ,
Li X ,
Koch U ,
Menninger S ,
Boros J ,
Habenberger P ,
Giavalisco P,
Cramer P ,
Denzel MS,
Nussbaumer P ,
Klebl B,
Falkenberg M ,
Gustafsson CM ,
Larsson NG
(2020) Nature , 588 , 712 - 716
,
Peter B ,
Hillen HS ,
Felser A ,
Bergbrede T ,
Choidas A ,
Horn M ,
Unger A ,
Di Lucrezia R ,
Atanassov I ,
Li X ,
Koch U ,
Menninger S ,
Boros J ,
Habenberger P ,
Giavalisco P,
Cramer P ,
Denzel MS,
Nussbaumer P ,
Klebl B,
Falkenberg M ,
Gustafsson CM ,
Larsson NG
(2020) Nature , 588 , 712 - 716
Grant Support:
- Swedish Research Council: 2015-00418 (Sweden)
- Swedish Research Council: 2013-3621 (Sweden)
- Swedish Research Council: 2012-2583 (Sweden)
- Knut and Alice Wallenberg Foundation: (Sweden)
- German Research Foundation (DFG): SFB1218/A06 (Germany)
- European Research Council (ERC): Advanced Grant 2016-741366 (Sweden)
- Swedish Research Council: ALFGBG-727491 (Sweden)
- Swedish Research Council: ALFGBG-728151 (Sweden)
- Swedish Research Council: SLL2018.0471 (Sweden)
- German Research Foundation (DFG): SFB860 (Germany)
- German Research Foundation (DFG): SPP1935 (Germany)
- European Research Council (ERC): 693023 (Germany)
- Volkswagen Foundation: (Germany)
- German Research Foundation (DFG): EXC 2067/1- 390729940 (Germany)
- German Research Foundation (DFG): FOR2848 (Germany)