EMD-11657
CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc
EMD-11657
Single-particle1.7 Å
Deposition: 22/08/2020Map released: 18/11/2020
Last modified: 13/11/2024
Sample Organism:
Homo sapiens,
Lama glama
Sample: Human GABA(A)R-beta3 homopentamer in complex with Megabody-25 in lipid nanodisc
Fitted models: 7a5v
Deposition Authors: Nakane T
,
Kotecha A
Sample: Human GABA(A)R-beta3 homopentamer in complex with Megabody-25 in lipid nanodisc
Fitted models: 7a5v
Deposition Authors: Nakane T
,
Kotecha A
Single-particle cryo-EM at atomic resolution.
Nakane T ,
Kotecha A ,
Sente A ,
McMullan G,
Masiulis S,
Brown PMGE,
Grigoras IT,
Malinauskaite L ,
Malinauskas T ,
Miehling J,
Uchanski T ,
Yu L,
Karia D,
Pechnikova EV,
de Jong E,
Keizer J,
Bischoff M,
McCormack J,
Tiemeijer P,
Hardwick SW ,
Chirgadze DY ,
Murshudov G,
Aricescu AR ,
Scheres SHW
(2020) Nature , 587 , 152 - 156
,
Kotecha A ,
Sente A ,
McMullan G,
Masiulis S,
Brown PMGE,
Grigoras IT,
Malinauskaite L ,
Malinauskas T ,
Miehling J,
Uchanski T ,
Yu L,
Karia D,
Pechnikova EV,
de Jong E,
Keizer J,
Bischoff M,
McCormack J,
Tiemeijer P,
Hardwick SW ,
Chirgadze DY ,
Murshudov G,
Aricescu AR ,
Scheres SHW
(2020) Nature , 587 , 152 - 156
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1012 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/L009609/1 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/15 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1013 (United Kingdom)
- Wellcome Trust: 206171/Z/17/Z (United Kingdom)
- Wellcome Trust: 202905/Z/16/Z) (United Kingdom)