Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-11624

Single-particle
4.1 Å
EMD-11624
3D View Gallery
Deposition: 17/08/2020
Map released: 01/12/2021
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-11624
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7a2g summary report (pdf.gz) Map and 7a2g FULL report (pdf.gz)
EMICSS annotations (xml)

Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH).

EMD-11624

Single-particle
4.1 Å
EMD-11624
3D View Gallery
Deposition: 17/08/2020
Map released: 01/12/2021
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Tyrosine hydroxylase
Fitted models: 7a2g

Deposition Authors: Bueno-Carrasco MT , Cuellar J
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Bueno-Carrasco MT , Cuellar J , Flydal MI , Santiago C , Krakenes TA , Kleppe R, Lopez-Blanco JR , Marcilla M , Teigen K , Alvira S , Chacon P , Martinez A , Valpuesta JM
(2022) Nat Commun , 13 , 74 - 74
PUBMED: 35013193
DOI: doi:10.1038/s41467-021-27657-y
ISSN: 2041-1723