Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-10694

Single-particle
4.1 Å
EMD-10694
3D View Gallery
Deposition: 25/02/2020
Map released: 23/09/2020
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-10694
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6y5d summary report (pdf.gz) Map and 6y5d FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of human cGAS (K394E) bound to the nucleosome

EMD-10694

Single-particle
4.1 Å
EMD-10694
3D View Gallery
Deposition: 25/02/2020
Map released: 23/09/2020
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of cGAS-NCP complex
Fitted models: 6y5d

Deposition Authors: Pathare GR , Cavadini S
Structural mechanism of cGAS inhibition by the nucleosome.
Pathare GR , Decout A , Gluck S , Cavadini S, Makasheva K , Hovius R , Kempf G, Weiss J , Kozicka Z , Guey B , Melenec P , Fierz B , Thoma NH , Ablasser A
(2020) Nature , 587 , 668 - 672
PUBMED: 32911482
DOI: doi:10.1038/s41586-020-2750-6
ISSN: 1476-4687
ASTM: NATUAS