EMD-10553
Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
EMD-10553
Helical reconstruction3.35 Å
Deposition: 16/12/2019Map released: 04/11/2020
Last modified: 09/10/2024
Sample Organism:
Homo sapiens
Sample: Uromodulin (UMOD)/Tamm-Horsfall protein (THP)
Fitted models: 6tqk
Deposition Authors: Stsiapanava A
,
Xu C
Sample: Uromodulin (UMOD)/Tamm-Horsfall protein (THP)
Fitted models: 6tqk
Deposition Authors: Stsiapanava A
,
Xu C
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Stsiapanava A ,
Xu C ,
Brunati M ,
Zamora-Caballero S ,
Schaeffer C ,
Bokhove M ,
Han L ,
Hebert H ,
Carroni M ,
Yasumasu S ,
Rampoldi L ,
Wu B ,
Jovine L
(2020) EMBO J , 39 , e106807 - e106807
,
Xu C ,
Brunati M ,
Zamora-Caballero S ,
Schaeffer C ,
Bokhove M ,
Han L ,
Hebert H ,
Carroni M ,
Yasumasu S ,
Rampoldi L ,
Wu B ,
Jovine L
(2020) EMBO J , 39 , e106807 - e106807
Secondary citations:
- Tamm I & Horsfall FL. (1950) Characterization and separation of an inhibitor of viral hemagglutination present in urine. Proc Soc Exp Biol Med, 74, 106 - 108
- Delain E, Thiery JP, Coulard D, Joliviene A & Hartman L. (1980) Etude chimique et ultrastructurale de la glycoproteine de Tamm et Horsfall ou uromucoide. Biol Cellulaire, 39, 31 - 42
- Pennica D, Kohr WJ, Kuang WJ, Glaister D, Aggarwal BB, Chen EY & Goeddel DV. (1987) Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. Science, 236, 83 - 88
- Jovine L, Qi H, Williams Z, Litscher E & Wassarman PM. (2002) The ZP domain is a conserved module for polymerization of extracellular proteins. Nat Cell Biol, 4, 457 - 461
- Serafini-Cessi F, Malagolini N & Cavallone D. (2003) Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis, 42, 658 - 676
- Jovine L, Qi H, Williams Z, Litscher ES & Wassarman PM. (2004) A duplicated motif controls assembly of zona pellucida domain proteins. PNAS, 101, 5922 - 5927
- Jovine L, Darie CC, Litscher ES & Wassarman PM. (2005) Zona pellucida domain proteins. Annu Rev Biophys, 74, 83 - 114
- Schaeffer C, Santambrogio S, Perucca S, Casari G & Rampoldi L. (2009) Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly. Mol Biol Cell, 20, 589 - 599
- Han L, Monne M, Okumura H, Schwend T, Cherry AL, Flot D, Matsuda T & Jovine L. (2010) Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3. Cell, 143, 404 - 415
- Rampoldi L, Scolari F, Amoroso A, Ghiggeri G & Devuyst O. (2011) The rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease. Kidney Int, 80, 338 - 347
- Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, Schaeffer C, Olinger E, Peng J, Santambrogio S, Perrier R, Li S, Bokhove M, Bachi A, Hummler E, Devuyst O, Wu Q, Jovine L & Rampoldi L. (2015) The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. eLife, 4, e08887
- Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L & Jovine L. (2016) A structured interdomain linker directs self-polymerization of human uromodulin. PNAS, 113, 1552 - 1557
- Bokhove M & Jovine L. (2018) Structure of zona pellucida module proteins. Curr Top Dev Biol, 130, 413 - 442
- Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Han L, Carroni M, Yasumasu S, Rampoldi L, Wu B & Jovine L. (2020) Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Grant Support:
- Swedish Research Council: 2016-03999 (Sweden)
- Knut and Alice Wallenberg Foundation: 2018.0042 (Sweden)
- Ministry of Education (MoE, Singapore): 2017-T1-001-168 (Singapore)
- Ministry of Education (MoE, Singapore): 2016-T2-1-010 (Singapore)