EMD-0342

Single-particle
4.2 Å
EMD-0342
3D View Gallery
Deposition: 20/11/2018
Map released: 23/01/2019
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-0342

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-6n4r summary report (pdf.gz) Map-6n4r FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2

EMD-0342

Single-particle
4.2 Å
EMD-0342
3D View Gallery
Deposition: 20/11/2018
Map released: 23/01/2019
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, Arcobacter butzleri (strain RM4018), Thrixopelma pruriens
Sample: Nav1.7 VSD2 in complex with ProTx2 and an anti-Nav Fab
Fitted models: 6n4r

Deposition Authors: Xu H, Rohou A
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A , Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM , Payandeh J
(2019) Cell , 176 , 702
PUBMED: 30661758
DOI: doi:10.1016/j.cell.2018.12.018
ISSN: 1097-4172