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EMD-0247
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
EMD-0247
Single-particle3.2 Å
Deposition: 14/09/2018Map released: 21/11/2018
Last modified: 13/11/2024
Sample Organism:
Homo sapiens,
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sample: Leucine zippered human insulin receptor ectodomain (IR-A isoform, "deltabeta" mutant) in complex with insulin and two Fv 83-7 modules : "upper" membrane-distal part
Fitted models: 6hn5
Deposition Authors: Weis F
,
Menting JG
Sample: Leucine zippered human insulin receptor ectodomain (IR-A isoform, "deltabeta" mutant) in complex with insulin and two Fv 83-7 modules : "upper" membrane-distal part
Fitted models: 6hn5
Deposition Authors: Weis F
,
Menting JG
The signalling conformation of the insulin receptor ectodomain.
Weis F ,
Menting JG ,
Margetts MB,
Chan SJ,
Xu Y,
Tennagels N,
Wohlfart P ,
Langer T ,
Muller CW ,
Dreyer MK ,
Lawrence MC
(2018) Nat Commun , 9 , 4420 - 4420
,
Menting JG ,
Margetts MB,
Chan SJ,
Xu Y,
Tennagels N,
Wohlfart P ,
Langer T ,
Muller CW ,
Dreyer MK ,
Lawrence MC
(2018) Nat Commun , 9 , 4420 - 4420
Grant Support:
- National Health and Medical Research Council (Australia): APP1099595 (Australia)
- National Health and Medical Research Council (Australia): APP1128553 (Australia)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): DK013914 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): UC DRTC DK020595 (United States)