CHEBI:50924 - sorafenib

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ChEBI Name sorafenib
Definition A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:47228
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Formula C21H16ClF3N4O3
Net Charge 0
Average Mass 464.826
Monoisotopic Mass 464.08630
InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
Roles Classification
Biological Role(s): EC (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC, a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
ferroptosis inducer
Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
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ChEBI Ontology
Outgoing sorafenib (CHEBI:50924) has role angiogenesis inhibitor (CHEBI:48422)
sorafenib (CHEBI:50924) has role anticoronaviral agent (CHEBI:149553)
sorafenib (CHEBI:50924) has role antineoplastic agent (CHEBI:35610)
sorafenib (CHEBI:50924) has role EC (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
sorafenib (CHEBI:50924) has role ferroptosis inducer (CHEBI:173085)
sorafenib (CHEBI:50924) has role tyrosine kinase inhibitor (CHEBI:38637)
sorafenib (CHEBI:50924) is a (trifluoromethyl)benzenes (CHEBI:83565)
sorafenib (CHEBI:50924) is a aromatic ether (CHEBI:35618)
sorafenib (CHEBI:50924) is a monochlorobenzenes (CHEBI:83403)
sorafenib (CHEBI:50924) is a phenylureas (CHEBI:134043)
sorafenib (CHEBI:50924) is a pyridinecarboxamide (CHEBI:25529)
Incoming sorafenib tosylate (CHEBI:50928) has part sorafenib (CHEBI:50924)
INNs Sources
sorafenib WHO MedNet
sorafénib WHO MedNet
sorafenib WHO MedNet
sorafenibum WHO MedNet
Synonyms Sources
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide ChemIDplus
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea ChemIDplus
Manual Xrefs Databases
2459 DrugCentral
DB00398 DrugBank
Sorafenib Wikipedia
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Registry Number Type Source
284461-73-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
18520294 PubMed citation Europe PMC
19568496 PubMed citation Europe PMC
19633425 PubMed citation Europe PMC
19821497 PubMed citation Europe PMC
36029544 PubMed citation Europe PMC
Last Modified
05 September 2022